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Bacterial Degradation of Quinoline and Derivatives—Pathways and Their Biocatalysts
Author(s) -
Fetzner Susanne,
Tshisuaka Barbara,
Lingens Franz,
Kappl Reinhard,
Hüttermann Jürgen
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980316)37:5<576::aid-anie576>3.0.co;2-l
Subject(s) - quinoline , chemistry , degradation (telecommunications) , enzyme , transformation (genetics) , biotransformation , molybdenum , microorganism , combinatorial chemistry , organic chemistry , biodegradation , biochemistry , bacteria , biology , computer science , telecommunications , genetics , gene
A series of interesting enzymes were discovered during investigations on the degradation of quinoline by microorganisms. These include the molybdenum‐containing hydroxylases that catalyze the transformation 1 → 2 and the unusual 2,4‐dioxygenases that catalyze the reaction 3 → 4 . The application of the hydroxylases may even be interesting in industry, because several quinoline derivatives are used as pharmaceuticals or agrochemicals.