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A New Catalyst System for the Heck Reaction of Unreactive Aryl Halides
Author(s) -
Reetz Manfred T.,
Lohmer Gunther,
Schwickardi Renate
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980302)37:4<481::aid-anie481>3.0.co;2-i
Subject(s) - halide , aryl , catalysis , heck reaction , chemistry , aryl halide , palladium , organic chemistry , medicinal chemistry , polymer chemistry , alkyl
A simple solution to the age‐old problem of the Heck reaction of cheap but unreactive chloro‐ and bromoarenes [for example, reaction (1)] has been found in the catalyst [Pd(CH 3 CN) 2 Cl 2 ]⋅6 Ph 4 PCl in the presence of N , N ‐dimethylglycine as additive. The reaction then proceeds with exceptionally high efficiency.