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A Self‐Replicating Peptide under Ionic Control
Author(s) -
Yao Shao,
Ghosh Indraneel,
Zutshi Reena,
Chmielewski Jean
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980302)37:4<478::aid-anie478>3.0.co;2-v
Subject(s) - autocatalysis , peptide , coiled coil , coupling (piping) , chemistry , electromagnetic coil , ionic bonding , biophysics , function (biology) , crystallography , materials science , physics , biochemistry , biology , ion , organic chemistry , microbiology and biotechnology , metallurgy , catalysis , quantum mechanics
The chemical coupling of two peptide fragments to give the peptide K1 K2 (shown in the helical wheel diagram on the right) is autocatalytic at high NaClO 4 concentrations (1 M ). Under these conditions K1 K2 assumes a coiled‐coil conformation, which can function as a template for the coupling. Autocatalysis is not observed under conditions that prevent formation of the coiled‐coil conformation.