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Electron Transfer through DNA in the Course of Radical‐Induced Strand Cleavage
Author(s) -
Meggers Eric,
Kusch Dirk,
Spichty Martin,
Wille Uta,
Giese Bernd
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980302)37:4<460::aid-anie460>3.0.co;2-u
Subject(s) - guanine , electron transfer , dna , cleavage (geology) , stacking , chemistry , photochemistry , yield (engineering) , biophysics , biochemistry , materials science , biology , nucleotide , organic chemistry , fracture (geology) , metallurgy , gene , composite material
No benefit from base stacking is observed for rates of electron transfer in DNA. This conclusion was drawn from experiments with a new DNA assay in which a radical cationic site, generated by strand cleavage, can be reduced by the guanine bases in the same DNA (the electron transfer is indicated by arrows in the diagram). The distance dependence of this electron transfer step is determined by the chemical yield of the reduction product.