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A Glucose‐Containing Ether Lipid (Glc‐PAF) as an Antiproliferative Analogue of the Platelet‐Activating Factor
Author(s) -
Mickeleit Michael,
Wieder Thomas,
Arnold Michael,
Geilen Christoph C.,
Mulzer Johann,
Reutter Werner
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980216)37:3<351::aid-anie351>3.0.co;2-p
Subject(s) - platelet activating factor , chemistry , phospholipid , ether , apoptosis , cell growth , programmed cell death , platelet , biochemistry , stereochemistry , organic chemistry , biology , endocrinology , immunology , membrane
A new group of active substances , to which 1 belongs, inhibit cell proliferation and initiate programmed cell death (apoptosis) in keratinocytes. The glucosylated phospholipid 1 was synthesized from (S) ‐isopropylideneglycerol in nine steps with an overall yield of 25 %.