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Copper‐Catalyzed Enantioselective Michael Additions: Recent Progress with New Phosphorus Ligands
Author(s) -
Krause Norbert
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980216)37:3<283::aid-anie283>3.0.co;2-9
Subject(s) - enantioselective synthesis , trifluoromethanesulfonate , michael reaction , copper , reagent , catalysis , ligand (biochemistry) , phosphorus , chemistry , combinatorial chemistry , addition reaction , organic chemistry , receptor , biochemistry
A breakthrough in copper‐catalyzed enantioselective Michael additions was achieved recently by Feringa et al. by using the chiral phosphorus amidite 1 . With few mol % of this ligand and copper( II ) triflate, highly enantioselective 1,4‐additions of diorganozinc reagents to numerous cyclic enones can be carried out.