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Phosphinic Acid Induced Reversal of Regioselectivity in Pd‐Catalyzed Hydrophosphinylation of Alkynes with Ph 2 P(O)H
Author(s) -
Han LiBiao,
Hua Ruimao,
Tanaka Masato
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980202)37:1/2<94::aid-anie94>3.0.co;2-t
Subject(s) - regioselectivity , catalysis , chemistry , drop (telecommunication) , oxide , medicinal chemistry , organic chemistry , computer science , telecommunications
One drop is enough to switch from hydropalladation to phosphinylpalladation. If one drop of diphenylphosphinic acid is added for the hydrophosphinylation of alkynes with diphenylphosphane oxide, there is a reversal in regioselectivity (as shown below).