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Total Synthesis of Altohyrtin A (Spongistatin 1): Part 1
Author(s) -
Guo Jiasheng,
Duffy Kevin J.,
Stevens Kirk L.,
Dalko Peter I.,
Roth Rebecca M.,
Hayward Matthew M.,
Kishi Yoshito
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980202)37:1/2<187::aid-anie187>3.0.co;2-d
Subject(s) - stereochemistry , chemistry , total synthesis
The most active compound of the extraordinarily cytotoxic spongipyrans, spongistatin 1, isolated from marine sponges, appeared to be identical to altohyrtin A. The total synthesis of this macrolide has now firmly established the relative and absolute stereochemistry proposed by Kitagawa (see picture below), and has also verified that altohyrtin A and spongistatin 1 are identical.