Premium
A Convergent Route for the Total Synthesis of the Eleuthesides
Author(s) -
Chen XiaoTao,
Gutteridge Clare E.,
Bhattacharya Samit K.,
Zhou Bishan,
Pettus Thomas R. R.,
Hascall Tony,
Danishefsky Samuel J.
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980202)37:1/2<185::aid-anie185>3.0.co;2-l
Subject(s) - total synthesis , stereochemistry , skeleton (computer programming) , stereoselectivity , chemistry , ring (chemistry) , sequence (biology) , tricyclic , combinatorial chemistry , computer science , organic chemistry , biochemistry , programming language , catalysis
A ring expansion/ring contraction sequence is one of the key steps in the stereoselective synthesis of the tricyclic eleutheside skeleton 2 from α ‐phellandrene 1 . Eleuthesides are natural products that are isolated from different marine sources, and several of these compounds display taxol‐like anticancer activity.