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Direct Synthesis of Ketones from Primary Alcohols and 1‐Alkenes
Author(s) -
Jun ChulHo,
Huh ChanWoo,
Na SangJin
Publication year - 1998
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/(sici)1521-3773(19980202)37:1/2<145::aid-anie145>3.0.co;2-0
Subject(s) - hydroacylation , primary (astronomy) , aryl , alcohol , catalysis , chemistry , intermolecular force , alkyl , organic chemistry , primary alcohol , alcohol oxidation , ketone , medicinal chemistry , aldehyde , molecule , physics , astronomy
Two consecutive catalytic reactions , the oxidation of a primary alcohol by hydrogen transfer and the subsequent intermolecular hydroacylation in the presence of 2‐amino‐4‐methylpyridine (AMP), take place in a generally applicable one‐pot synthesis of ketones from primary alcohols and 1‐alkenes catalyzed by transition metals [Eq. (a)]; R = aryl, R′ = alkyl.