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Oxepinamides A‐C and Fumiquinazolines H‐I: Bioactive Metabolites from a Marine Isolate of a Fungus of the Genus Acremonium
Author(s) -
Belofsky Gilbert N.,
Anguera Montserrat,
Jensen Paul R.,
Fenical William,
Köck Matthias
Publication year - 2000
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(20000417)6:8<1355::aid-chem1355>3.0.co;2-s
Subject(s) - fungus , candida albicans , broth microdilution , mycelium , tunicate , chemistry , marine fungi , antifungal , mass spectrometry , microbiology and biotechnology , biology , chromatography , botany , antimicrobial , ecology , minimum inhibitory concentration
Three new oxepin‐containing natural products ( 1 – 3 ) and two new fumiquinazoline metabolites ( 4 – 5 ) have been isolated from organic extracts of the culture broth and mycelia of an Acremonium sp., a fungus obtained from the surface of the Caribbean tunicate Ecteinascidia turbinata . The structures of the five compounds were determined through extensive analysis of 1D‐ and 2D‐NMR data, and mass spectrometry. Compound 1 exhibited good anti‐inflammatory activity in a topical RTX‐induced mouse ear edema assay. Compounds 4 and 5 exhibited weak antifungal activity toward Candida albicans in a broth microdilution assay.