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New Polyfunctional Magnesium Reagents for Organic Synthesis
Author(s) -
Rottländer Mario,
Boymond Laure,
Bérillon Laurent,
Leprêtre Anne,
Varchi Greta,
Avolio Salvatore,
Laaziri Hamid,
Quéguiner Guy,
Ricci Alfredo,
Cahiez Gérard,
Knochel Paul
Publication year - 2000
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(20000303)6:5<767::aid-chem767>3.0.co;2-x
Subject(s) - magnesium , reagent , chemistry , halogen , aryl , reactivity (psychology) , organic synthesis , iodine , halide , inorganic chemistry , catalysis , organic chemistry , medicinal chemistry , alkyl , medicine , alternative medicine , pathology
The iodine‐magnesium exchange reaction allows the preparation of polyfunctional aryl, heteroaryl, or alkenyl magnesium reagents at low temperature. These reagents display the typical reactivity of Grignard compounds and undergo various copper‐catalyzed reactions such as allylation or 1,4‐addition. Using this halogen‐metal exchange reaction, it was possible to generate polyfunctional magnesium reagents on the solid phase.