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Platinum‐Catalysed Allylic Alkylation: Reactivity, Enantioselectivity, and Regioselectivity
Author(s) -
Blacker A. John,
Clarke Matthew L.,
Loft Michael S.,
Mahon Mary F.,
Humphries Mark E.,
Williams Jonathan M. J.
Publication year - 2000
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(20000117)6:2<353::aid-chem353>3.0.co;2-u
Subject(s) - regioselectivity , chemistry , tsuji–trost reaction , palladium , platinum , ligand (biochemistry) , allylic rearrangement , alkylation , enantioselective synthesis , reactivity (psychology) , stereochemistry , medicinal chemistry , substitution reaction , catalysis , tricyclohexylphosphine , organic chemistry , phosphine , receptor , medicine , biochemistry , alternative medicine , pathology
Platinum complexes of phosphino‐oxazoline ligands catalyse allylic alkylations with good yields and enantioselectivity (see diagram), but show interesting differences compared to similar palladium complexes. Highly regioselective alkylation of mono(alkyl)‐substituted allylic acetates is observed when Cy 3 P is used as ligand.