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Recognition of Abasic Sites in DNA by a Cyclobisacridine Molecule
Author(s) -
Berthet Nathalie,
Michon Josette,
Lhomme Jean,
TeuladeFichou MariePaule,
Vigneron Jean Pierre,
Lehn JeanMarie
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19991203)5:12<3625::aid-chem3625>3.0.co;2-g
Subject(s) - ap site , oligonucleotide , dna , chemistry , cleavage (geology) , binding site , microbiology and biotechnology , dna damage , biochemistry , biology , paleontology , fracture (geology)
The selective binding of cyclobisacridine ( CBA ) to DNA duplexes containing a stable analogue of the abasic site was demonstrated by T m , EPR, and photocleavage experiments. The abasic site recognition was evidenced by cleavage of an oligonucleotide containing an apurinic site.