Premium
Stereoselective Conjugate Addition of Nitrogen and Carbon Nucleophiles to Sugar‐Derived Enones: Synthesis of Sialic Acid Analogues
Author(s) -
Dondoni Alessandro,
Marra Alberto,
Boscarato Alessia
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19991203)5:12<3562::aid-chem3562>3.0.co;2-w
Subject(s) - sialic acid , conjugate , nucleophile , glycolipid , chemistry , sugar , biochemistry , stereoselectivity , glycoprotein , amino sugar , stereochemistry , catalysis , mathematical analysis , mathematics
Given the widespread occurrence of sialic acids in glycoproteins, glycolipids, and oligosaccharides and the essential role that these sialyl conjugates play in molecular recognition by infectious pathogens, in cell adhesion and differentiation phenomena, it is important to prepare analogues, such as 1 and 2 , since these compounds are potential inhibitors of the above biological processes.