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Cobalt‐Mediated [2+2+2] Cycloadditions of Pyrimidine Derivatives to Alkynes
Author(s) -
Pelissier Hélène,
Rodriguez Jean,
Vollhardt K. Peter C.
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19991203)5:12<3549::aid-chem3549>3.0.co;2-v
Subject(s) - cobalt , cycloaddition , pyrimidine , stereoselectivity , chemistry , quinazoline , medicinal chemistry , combinatorial chemistry , organic chemistry , stereochemistry , catalysis
Novel dihydropyrido[3,2‐ ij ]quinazoline cobalt complexes were synthesized from the cocyclization reaction of 1‐alkynyl pyrimidines with disubstituted alkynes. The chemo‐, regio‐, and stereoselective participation of pyrimidine derivatives in cobalt‐mediated [2+2+2] cycloaddition reactions were investigated as a new synthetic entry to modified nucleosides.