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Influence of the Molecular Surface Characteristics of the Diastereoisomers of a Quartet Molecule on their Physicochemical Properties: A Linear Solvation Free‐Energy Study
Author(s) -
Ventosa Nora,
RuizMolina Daniel,
Sedó Josep,
Rovira Concepció,
Tomas Xavier,
André JeanJacques,
Bieber André,
Veciana Jaume
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19991203)5:12<3533::aid-chem3533>3.0.co;2-w
Subject(s) - diastereomer , molecule , solvation , isomerization , chemistry , amorphous solid , chemical physics , surface (topology) , fractal dimension , computational chemistry , stereochemistry , crystallography , fractal , organic chemistry , mathematical analysis , geometry , mathematics , catalysis
The difference in ability of a quartet molecule to interact with the neighboring solvent molecules is influenced by the molecular surface characteristics of the two diastereomers of the molecule. Therefore, molecular parameters like the surface area and the fractal dimension (see figure) control some of their physicochemical properties, such as their differential chromatographic retention of these two diastereomers, their isomerization equilibrium, and tumbling processes in solid or viscous amorphous matrices.