Premium
Solid‐Phase Synthesis of 2,4,6‐Triaminopyrimidines
Author(s) -
Guillier Fabrice,
Roussel Patrick,
Moser Heinz,
Kane Peter,
Bradley Mark
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19991203)5:12<3450::aid-chem3450>3.0.co;2-f
Subject(s) - phase (matter) , materials science , computer science , chemistry , organic chemistry
A library of various 2,4,6‐triaminopyrimidines was prepared by a solid‐phase approach with a ring‐activation/amination process (see scheme). Regio‐ and chemoselectivity could be controlled by a careful choice of leaving groups. The use of high temperature (140 °C) and neat amines show the advantages of solid‐phase synthesis, since high purities and acceptable yields of substituted pyrimidines were obtained.