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First Total Synthesis and Determination of the Absolute Configuration of the Stress Factor (+)‐Hydroxymyoporone
Author(s) -
Tietze Lutz F.,
Wegner Christoph,
Wulff Christian
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19991001)5:10<2885::aid-chem2885>3.0.co;2-8
Subject(s) - enantioselective synthesis , absolute configuration , absolute (philosophy) , ketone , stereoselectivity , stereochemistry , total synthesis , chemistry , organic chemistry , philosophy , catalysis , epistemology
The asymmetric allylation of a methyl ketone which proceeds with nearly complete stereoselectivity is the key step in the enantioselective synthesis of the stress factor (+)‐hydroxymyoporone. This also allows a reassignment of its absolute configuration.