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C‐1′ Radical‐Based Approaches for the Synthesis of Anomeric Spironucleosides
Author(s) -
Chatgilialoglu Chryssostomos,
Gimisis Thanasis,
Spada Gian Piero
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19991001)5:10<2866::aid-chem2866>3.0.co;2-6
Subject(s) - anomer , chemistry , alkoxy group , radical cyclization , stereochemistry , cascade , organic chemistry , alkyl , chromatography
A 1,5‐radical translocation from a conveniently situated alkoxyl or vinyl radical next to the C‐1′ position is the key step for the successful radical‐based cascade reactions that allow the construction of two classes of anomeric spironucleosides 1 and 2 in the ribo and 2′‐deoxyribo series.