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General and Asymmetric Synthesis of Protected 1,3,5‐Triols with Pendant Functional Groups
Author(s) -
Schneider Christoph,
Rehfeuter Markus
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19991001)5:10<2850::aid-chem2850>3.0.co;2-7
Subject(s) - polyene , enantiopure drug , stereoselectivity , double bond , polyol , chemistry , combinatorial chemistry , stereochemistry , functional group , terminal (telecommunication) , enantioselective synthesis , computer science , organic chemistry , catalysis , telecommunications , polymer , polyurethane
The efficient and stereoselective synthesis of protected 1,3,5‐triols 2 of any configuration can be achieved starting from the common advanced intermediate 1 . The terminal double bond in 2 can be used subsequently to prepare two different building blocks for a coupling reaction. This strategy should provide a very efficient access to enantiopure polyol chains commonly found in polyene macrolide antibiotics.