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Substrate‐Directed Diastereoselective Hydroformylation: Key Step for the Assembly of Polypropionate Subunits
Author(s) -
Breit Bernhard,
Dauber Mario,
Harms Klaus
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19991001)5:10<2819::aid-chem2819>3.0.co;2-z
Subject(s) - hydroformylation , polyketide , key (lock) , substrate (aquarium) , chemistry , stereochemistry , combinatorial chemistry , computer science , catalysis , organic chemistry , biology , rhodium , enzyme , ecology , computer security , biosynthesis
o ‐DPPB‐Directed hydroformylation could serve as a key step for the construction of bifunctionalized stereotriad building blocks, which form the basis of polyketide natural products (see scheme). The prepared building blocks are well suited to permit polyketide chain extensions into both directions of the main chain. o ‐DPPB= ortho ‐diphenylphosphanylbenzoyl.