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Syntheses of (−)‐Epothilone B
Author(s) -
Schinzer Dieter,
Bauer Armin,
Schieber Jennifer
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19990903)5:9<2492::aid-chem2492>3.0.co;2-r
Subject(s) - epothilones , epothilone , ixabepilone , stereochemistry , chemistry , biology , cancer , metastatic breast cancer , breast cancer , genetics
Epothilones 1 ( 1 A : R = H; 1 B : R = Me) as promising, new microtubule‐stabilizing natural products with taxol‐like biological activity were isolated from myxo bacteria. A flexible and convergent total synthesis of epothilone A ( 1 A ) and two formal total syntheses of epothilone B ( 1 B ) for an easy and facile access to epothilones are reported.