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Effects of (N7)‐Coordinated Nickel( II ), Copper( II ), or Platinum( II ) on the Acid–Base Properties of Guanine Derivatives and Other Related Purines [≠]
Author(s) -
Song Bin,
Zhao Jing,
Griesser Rolf,
Meiser Cordula,
Sigel Helmut,
Lippert Bernhard
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19990802)5:8<2374::aid-chem2374>3.0.co;2-s
Subject(s) - guanine , nucleobase , chemistry , nucleic acid , purine metabolism , platinum , nickel , base (topology) , copper , cisplatin , residue (chemistry) , stereochemistry , combinatorial chemistry , inorganic chemistry , medicinal chemistry , dna , nucleotide , biochemistry , organic chemistry , enzyme , biology , catalysis , mathematics , mathematical analysis , genetics , chemotherapy , gene
Guanine is an important nucleobase residue in nucleic acids ; for example, the anticancer drug cisplatin , c is ‐[(NH 3 ) 2 PtCl 2 ], preferably binds to N7 of this site. In this study the effect of (N7)‐coordinated Ni 2+ (which is expected to correspond to that of Zn 2+ ), Cu 2+ , and cis‐ a 2 Pt 2+ or trans ‐a 2 Pt 2+ (where a = NH 3 or CH 3 NH 2 ) on the acid–base properties of guanine derivatives (see diagram) is quantified. Several related purines are included for comparison. Micro‐acidity‐constant evaluations are presented and more than 60 acidity constants are listed.