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Evidence for Direct Hydride Delivery from Formic Acid in Transfer Hydrogenation
Author(s) -
Yu Jinquan,
Spencer Jonathan B.
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19990802)5:8<2237::aid-chem2237>3.0.co;2-o
Subject(s) - formic acid , decarboxylation , hydride , regioselectivity , chemistry , hydrogen , transfer hydrogenation , hydrogen atom , photochemistry , metal , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , ruthenium , alkyl
Regioselectivity of hydrometalation shows that the two hydrogen atoms of formic acid are not scrambled during transfer hydrogenation. It is proposed that delivery of the hydrogen atom from the formyl position is concerted with decarboxylation (shown here) rather than through formation of a metal dihydro species.