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Towards Genoelectronics: Electrochemical Biosensing of DNA Hybridization
Author(s) -
Wang Joseph
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19990604)5:6<1681::aid-chem1681>3.0.co;2-u
Subject(s) - biosensor , dna , nucleic acid , nanotechnology , dna–dna hybridization , nucleic acid thermodynamics , electrochemistry , computational biology , computer science , hybridization probe , interface (matter) , scale (ratio) , biology , materials science , chemistry , genetics , physics , electrode , base sequence , bubble , quantum mechanics , maximum bubble pressure method , parallel computing
Innovative strategies for DNA diagnostics based on the interface of electronic and nucleic acid recognition systems are described. Particular attention is given to new routes for the direct electrical detection of hybridization events (illustrated here), and to the use of electrochemical fields for modulating DNA interactions. The new genoelectronic schemes offer great promise for large‐scale genetic testing.