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New Directions in the Synthesis of Glycopeptide Mimetics
Author(s) -
Marcaurelle Lisa A.,
Bertozzi Carolyn R.
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19990503)5:5<1384::aid-chem1384>3.0.co;2-x
Subject(s) - glycopeptide , thioether , oxime , combinatorial chemistry , chemistry , computational biology , biology , stereochemistry , biochemistry , antibiotics
Structural and functional mimetics of naturally occurring glycopeptides are attractive synthetic targets owing to their potential as biological tools and therapeutic agents. The syntheses of C ‐ and S ‐glycopeptides, glycopeptoids, and oxime‐ (figure) and thioether‐linked glycopeptides have now been realized, and many of these mimetics are currently undergoing biological evaluation.