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A Novel Direct Glycosylation Approach for the Synthesis of Dimers of N ‐Acetylneuraminic Acid
Author(s) -
Demchenko Alexei V.,
Boons GeertJan
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19990401)5:4<1278::aid-chem1278>3.0.co;2-l
Subject(s) - glycosylation , n acetylneuraminic acid , chemistry , acetylation , glycosyl , moiety , glycosyl donor , stereochemistry , neuraminic acid , derivative (finance) , combinatorial chemistry , biochemistry , sialic acid , financial economics , economics , gene
Surprisingly , further acetylation of the N ‐acetyl moiety of a 2‐methylthio neuraminyl derivative provides a glycosyl donor which proved to be very efficient in the glycosylation of the 8‐hydroxyl function of N ‐acetylneuraminic acid acceptors (Equation).