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Spectral Discrimination of Chiral Macrocyclic Paramagnetic Metal Complexes by NMR Techniques ≠
Author(s) -
Aime Silvio,
Botta Mauro,
Crich Simonetta Geninatti,
Terreno Enzo,
Anelli Pier Lucio,
Uggeri Fulvio
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19990401)5:4<1261::aid-chem1261>3.0.co;2-s
Subject(s) - paramagnetism , lanthanide , enantiomer , chemistry , aqueous solution , hydrogen bond , optically active , axial symmetry , metal , proton nmr , substrate (aquarium) , molecule , ion , stereochemistry , organic chemistry , physics , structural engineering , quantum mechanics , engineering , oceanography , geology
Axially symmetric macrocyclic polyaza complexes of lanthanide( III ) ions are present in aqueous solution as a racemic mixture of two enantiomers in slow exchange at room temperature. Chiral resolution of an anionic paramagnetic complex has been achieved by exploiting multisite electrostatic and hydrogen‐bonding interactions with an optically active organic base, and revealed by NMR techniques as illustrated. The bonding of the optically active substrate to the complex has been elucidated.