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Gd(DTPA‐bisamide)alkyl Copolymers: A Hint for the Formation of MRI Contrast Agents with Very High Relaxivity
Author(s) -
Tóth Éva,
Helm Lothar,
Kellar Kenneth E.,
Merbach André E.
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19990401)5:4<1202::aid-chem1202>3.0.co;2-y
Subject(s) - copolymer , polymer , proton , polymerization , alkyl , materials science , rotation (mathematics) , contrast (vision) , polymer chemistry , chemistry , nuclear magnetic resonance , organic chemistry , physics , geometry , mathematics , quantum mechanics , optics , composite material
The separation of global and local motion for [Gd(DTPA−BA)−(CH 2 ) n ] x copolymers (see diagram) shows that, contrary to usual linear polymers, the global rotation can strongly contribute to proton relaxivity. The rate and mechanism of water exchange is not influenced by polymerization. The collective results for these three polymers have important implications for the design of polymeric species with very high proton relaxivities.