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Synthetic Analogues for Oxovanadium( IV )–Glutathione Interaction: An EPR, Synthetic and Structural Study of Oxovanadium( IV ) Compounds with Sulfhydryl‐Containing Pseudopeptides and Dipeptides
Author(s) -
Tasiopoulos Anastasios J.,
Troganis Anastasios N.,
Evangelou Angelos,
Raptopoulou Catherine P.,
Terzis Aris,
Deligiannakis Yiannis,
Kabanos Themistoklis A.
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19990301)5:3<910::aid-chem910>3.0.co;2-#
Subject(s) - chemistry , glutathione , combinatorial chemistry , peptide , organic chemistry , biochemistry , enzyme
Glutathione , which is found in millimolar concentrations in all animal cells, plays an important role in the biochemistry of vanadium. Sulfhydryl‐containing peptides (or pseudopeptides) are ideal for the synthesis of analogues of the V IV O 2+ –glutathione species; such compounds were synthesized and characterized. Possible structures for the V IV O 2+ –glutathione center (shown here) at various pHs are proposed.