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Evidence for a Trajectory of Hydrolytic Reactions brought about by [L 3 Zn−OH] Species
Author(s) -
Rombach Michael,
Maurer Carsten,
Weis Karl,
Keller Egbert,
Vahrenkamp Heinrich
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19990301)5:3<1013::aid-chem1013>3.0.co;2-3
Subject(s) - pseudorotation , zinc , hydrolysis , chemistry , stereochemistry , computational chemistry , medicinal chemistry , organic chemistry , ring (chemistry)
A proposal for a detailed geometrical pathway for the hydrolysis of substrates Y 2 PO−X and RCO−X, under the influence of zinc complexes or hydrolytic zinc enzymes, has been yielded by the combination of a kinetic study and a structure correlation analysis (see diagram). The essentials of this pathway are a four‐center interaction between the Zn−OH and P−X or C−X units in the activation process and a Berry pseudorotation at zinc during the bond‐breaking/bond‐making process.