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Benzene‐Bridged Hexaalkynylphenylalanines and First‐Generation Dendrimers Thereof
Author(s) -
Kayser Bernd,
Altman Janina,
Beck Wolfgang
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19990201)5:2<754::aid-chem754>3.0.co;2-e
Subject(s) - dendrimer , hexa , amine gas treating , benzene , yield (engineering) , chemistry , carboxylate , palladium , organic chemistry , medicinal chemistry , materials science , catalysis , metallurgy
The palladium‐mediated coupling of p ‐ethynylphenylalanine ( p ‐epa) with hexabromobenzene afforded the benzene‐bridged hexaalkynyl α ‐amino acid 1 in high yield. Deprotection of 1 at the carboxylate terminus yielded the free hexa acid which was treated with amine H 2 NC(CH 2 OCH 2 CH 2 CO 2 CH 3 ) 3 to give a hexapodal first‐generation dendrimer.