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Chemoenzymatic Synthesis of Nucleopeptides
Author(s) -
Flohr Stefanie,
Jungmann Volker,
Waldmann Herbert
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19990201)5:2<669::aid-chem669>3.0.co;2-v
Subject(s) - nucleobase , peptide , nucleotide , covalent bond , chemistry , combinatorial chemistry , protecting group , biochemistry , peptide synthesis , stereochemistry , organic chemistry , dna , gene , alkyl
Enzymatic removal of protecting groups from the peptide, the nucleobase, and the carbohydrate parts are the key steps in the efficient synthesis of nucleopeptides, in which peptide chains are covalently linked to nucleotides (see scheme).