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Total Synthesis of Brevetoxin A: Part 4: Final Stages and Completion
Author(s) -
Nicolaou K. C.,
Gunzner Janet L.,
Shi Guoqiang,
Agrios Konstantinos A.,
Gärtner Peter,
Yang Zhen
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19990201)5:2<646::aid-chem646>3.0.co;2-e
Subject(s) - total synthesis , ring (chemistry) , key (lock) , wittig reaction , stereochemistry , completion (oil and gas wells) , chemistry , combinatorial chemistry , organic chemistry , computer science , engineering , computer security , petroleum engineering
A ten‐year campaign was successfully completed by the first total synthesis of brevetoxin A ( 1 ). A Horner–Wittig type coupling of suitably functionalized BCDE and GHIJ ring systems proved to be the last key step in the total synthesis of this architecturally beautiful molecule.