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Conformational Differences Between C ‐ and O ‐Glycosides: The α ‐ C ‐Mannobiose/ α ‐ O ‐Mannobiose Case
Author(s) -
Espinosa JuanFélix,
Bruix Marta,
Jarreton Olivier,
Skrydstrup Troels,
Beau JeanMarie,
JiménezBarbero Jesús
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19990201)5:2<442::aid-chem442>3.0.co;2-1
Subject(s) - chemistry , stereochemistry , molecular mechanics , nuclear magnetic resonance spectroscopy , computational chemistry , molecular dynamics
NMR spectroscopy and molecular mechanics calculations have demonstrated that the conformational behavior of α ‐ C ‐mannobiose ( 1 ) is rather different from that of its natural analogue Man α (1→2)Man ( 2 ); this has implications for the possibility of biological use of C ‐disaccharides.