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Discrimination of Enantiotopic Iodine Atoms by an Iodine/Magnesium Exchange Reaction
Author(s) -
Schulze Volker,
Hoffmann Reinhard W.
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19990104)5:1<337::aid-chem337>3.0.co;2-p
Subject(s) - iodine , stereoselectivity , reagent , magnesium , chemistry , combinatorial chemistry , organic chemistry , catalysis
Differentiation of enantiotopic groups is an alternative in stereoselective synthesis to the standard way of differentiating enantiotopic faces. Chiral Grignard reagents are able to differentiate the enantiotopic iodine atoms of 1,1‐diiodoalkanes and lead to enantiomerically enriched configurationally stable α ‐iodoalkylmagnesium reagents [Eq. (1)].