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Glycosyl Inositol Derivatives Related to Inositolphosphoglycan Mediators: Synthesis, Structure, and Biological Activity
Author(s) -
Dietrich Hansjörg,
Espinosa Juan Felix,
Chiara José Luis,
JimenezBarbero Jesús,
Leon Yolanda,
VarelaNieto Isabel,
Mato JoséMaria,
Cano Felix H.,
FocesFoces Concepción,
MartínLomas Manuel
Publication year - 1999
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19990104)5:1<320::aid-chem320>3.0.co;2-k
Subject(s) - inositol , signal transduction , intracellular , chemistry , phosphatidylinositol , inositol phosphate , mechanism (biology) , microbiology and biotechnology , biochemistry , biological activity , biology , receptor , in vitro , philosophy , epistemology
The development of effective strategies for the synthesis of phosphatidylinositol precursors such as that which contains the trisaccharide 1 , the study of their conformational features and dynamics, and the investigation of their biological properties may result in a better understanding of the mechanism of signal transduction of insulin and a number of growth factors. This new pathway of intracellular signalling has been postulated to proceed through uncharacterized inositolphosphoglycan mediators containing substructures such as 1 .