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Cyclodextrin‐Scaffolded Glycoclusters
Author(s) -
OrtizMellet Carmen,
Benito Juan M.,
García Fernández José M.,
Law Ho,
Chmurski Kazimierz,
Defaye Jacques,
O'Sullivan Mary L.,
Caro Hugo N.
Publication year - 1998
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19981204)4:12<2523::aid-chem2523>3.0.co;2-2
Subject(s) - cyclodextrin , chemistry , aryl , combinatorial chemistry , alkyl , sugar , stereochemistry , nanotechnology , organic chemistry , materials science
Fully carbohydrate glycoclusters featuring a hydrophobic cavity and an outer seven‐fold symmetric saccharide patch (see picture) have been efficiently prepared in two steps from readily available sugar isothiocyanates and per‐(6‐amino‐6‐deoxy)‐ β ‐cyclodextrin. The flexiblility of this strategy, compatible with the use of alkyl or aryl spacers, and its potential for the design of specific‐site‐delivery drug carriers are outlined. R = H, β ‐ D ‐Glc p , β ‐ D ‐Gal p