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An Enzyme‐Initiated Hydroxylation–Oxidation Carbo Diels–Alder Domino Reaction
Author(s) -
Müller Gernot H.,
Lang Andreas,
Seithel Dominic R.,
Waldmann Herbert
Publication year - 1998
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19981204)4:12<2513::aid-chem2513>3.0.co;2-4
Subject(s) - hydroxylation , phenols , chemistry , organic chemistry , domino , diels–alder reaction , bicyclic molecule , enzyme , catalysis
Abstract A novel combination of enzymatic and nonenzymatic steps in a domino process has been successfully demonstrated. A biocatalyzed hyroxylation and oxidation of phenols (tyrosinase, CHCl 3 , O 2 ) was linked to a Diels–Alder reaction and a subsequent allylation of the intermediary formed bicyclic diketones.