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Efficient Synthesis of the Pharmacophore of the Highly Potent Antitumor Antibiotic CC‐1065
Author(s) -
Tietze Lutz F.,
Buhr Wilm,
Looft Jan,
Grote Thomas
Publication year - 1998
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19980807)4:8<1554::aid-chem1554>3.0.co;2-j
Subject(s) - pharmacophore , moiety , chemistry , stereochemistry , combinatorial chemistry , antibiotics , bromobenzene , biochemistry , catalysis
Three steps suffice for the construction of the pyrroloindolino framework of the pharmacophoric moiety 2 of the highly potent anticancer agent CC‐1065. The easily accessible bis(allylamino)bromobenzene 1 was transformed by successive cyclizations mediated by Cp 2 ZrMeCl and by a Pd 0 complex.