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Stabilization of DNA Triple Helices by Crescent‐Shaped Dibenzophenanthrolines
Author(s) -
Baudoin Olivier,
Marchand Christophe,
TeuladeFichou MariePaule,
Vigneron JeanPierre,
Sun JianSheng,
Garestier Thérèse,
Hélène Claude,
Lehn JeanMarie
Publication year - 1998
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19980807)4:8<1504::aid-chem1504>3.0.co;2-t
Subject(s) - triple helix , dna , chemistry , crystallography , stereochemistry , biochemistry
Improving the stability of DNA triple helices is of great interest in the current development of antigene strategies. New aminoalkyl dibenzophenanthrolines, which have a large angular aromatic structure (right), are efficient triplex‐stabilizing ligands for this purpose.