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Synthesis of Natural Products By Rhodium‐Mediated Intramolecular C–H Insertion
Author(s) -
Taber Douglass F.,
Stiriba SalahE.
Publication year - 1998
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19980615)4:6<990::aid-chem990>3.0.co;2-u
Subject(s) - intramolecular force , rhodium , natural product , chemistry , stereochemistry , total synthesis , combinatorial chemistry , catalysis , organic chemistry
The strategic advantages of the Rh‐mediated intramolecular C–H insertion, which has been used as the key step in several natural product syntheses, are described here. The most recent such synthesis is the elegant route to (+)‐morphine shown below.