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Acid–Base and Metal‐Ion‐Binding Properties of the Quaternary [ cis ‐(NH 3 ) 2 Pt(dGuo)(dGMP)] Complex Formed Between cis ‐Diammineplatinum( II ), 2′‐Deoxyguanosine (dGuo), and 2′‐Deoxyguanosine 5′‐Monophosphate (dGMP 2− ) in Aqueous Solution
Author(s) -
Sigel Helmut,
Song Bin,
Oswald Gerda,
Lippert Bernhard
Publication year - 1998
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19980615)4:6<1053::aid-chem1053>3.0.co;2-l
Subject(s) - chemistry , potentiometric titration , deoxyguanosine , metal , titration , aqueous solution , base (topology) , metal ions in aqueous solution , inorganic chemistry , nucleotide , stereochemistry , medicinal chemistry , dna , ion , organic chemistry , biochemistry , mathematical analysis , mathematics , gene
For the first time the acid–base and metal‐ion‐binding properties of a quaternary Pt II complex (right) were studied (potentiometric pH titrations). The release of the protons from the two H(N1) sites is facilitated by the N7‐coordinated Pt II on average by Δp K a ≈0.8, and from the ‐P(O) 2 (OH) − residue by Δp K a = 0.44. Formation of the quinternary [M{ cis ‐(NH 3 ) 2 Pt(dGuo)(dGMP)}] 2+ complexes (M 2+ = Mg 2+ , Cu 2+ , Zn 2+ ) via the ‐PO 3 2− group is only slightly inhibited compared with the coordination tendency expected from its basicity. Several conclusions regarding DNA and the participation of nucleotides as substrates in enzymic reactions are presented.