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Efficient Chemoenzymatic Synthesis of Enantiomerically Pure α ‐Amino Acids
Author(s) -
Beller Matthias,
Eckert Markus,
Geissler Holger,
Napierski Bernd,
Rebenstock HeinzPeter,
Holla E. Wolfgang
Publication year - 1998
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19980515)4:5<935::aid-chem935>3.0.co;2-#
Subject(s) - enantioselective synthesis , hydrolysis , amino acid , palladium , chemistry , organic chemistry , catalysis , biocatalysis , combinatorial chemistry , biochemistry , reaction mechanism
A “state of the art” route to enantiomerically pure synthetic α ‐amino acids on a multigram scale from commonly available starting materials (below) is described; it relies on the combination of palladium‐catalyzed amidocarbonylation and enantioselective enzymatic hydrolysis.