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A Supramolecular Cytochrome P450 Mimic
Author(s) -
Schenning Albertus P. H. J.,
Lutje Spelberg Jeffrey H.,
Hubert Dominicus H. W.,
Feiters Martinus C.,
Nolte Roeland J. M.
Publication year - 1998
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19980515)4:5<871::aid-chem871>3.0.co;2-3
Subject(s) - rhodium , supramolecular chemistry , porphyrin , dehydrogenation , chemistry , catalysis , vesicle , formate , bilayer , photochemistry , supramolecular assembly , amphiphile , manganese , cytochrome p450 , stereochemistry , enzyme , combinatorial chemistry , organic chemistry , membrane , crystal structure , biochemistry , copolymer , polymer
Turnover numbers comparable to those of the enzyme itself in the catalytic epoxidation of alkenes are attained by a supramolecular cytochrome P450 mimic, in which an amphiphilic rhodium complex and a manganese porphyrin are incorporated in a dihexadecyl phosphate vesicle bilayer (shown schematically above). The electrons required for activation of dioxygen are supplied by rhodium‐catalyzed dehydrogenation of formate ions.