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Stereospecific and Kinetic Control over the Hydrolysis of a Sterically Hindered Platinum Picoline Anticancer Complex
Author(s) -
Chen Yu,
Guo Zijian,
Parsons Simon,
Sadler Peter J.
Publication year - 1998
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19980416)4:4<672::aid-chem672>3.0.co;2-8
Subject(s) - picoline , steric effects , chemistry , platinum , reactivity (psychology) , stereospecificity , adduct , hydrolysis , stereochemistry , ligand (biochemistry) , medicinal chemistry , pyridine , organic chemistry , catalysis , biochemistry , medicine , alternative medicine , receptor , pathology
The new anticancer complex cis ‐[PtCl 2 ( 15 NH 3 )(2‐picoline)] ( 1 ) and its 3‐picoline analogue differ from cisplatin in reactivity. The hydrolysis rates for each chloride ligand of the two complexes and the p K a values of their aqua and diaqua adducts have been determined by [ 1 H, 15 N] 2 D NMR spectroscopy. These data, together with X‐ray crystal structures, provide an explanation for the difference.