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Self‐Replication of Hexadeoxynucleotide Analogues: Autocatalysis versus Cross‐Catalysis
Author(s) -
Sievers Dirk,
von Kiedrowski Günter
Publication year - 1998
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19980416)4:4<629::aid-chem629>3.0.co;2-0
Subject(s) - template , autocatalysis , replication (statistics) , yield (engineering) , chemistry , stereochemistry , catalysis , combinatorial chemistry , nanotechnology , biology , biochemistry , materials science , virology , metallurgy
To pedal a replication bicycle (right) the “combinatorial” synthesis of four templates (AA′, BB′, AB′, BA′) from four components parts (A, A′, B, B′) is necessary. Two combinations yield a pair of complementary templates (AA′, BB′) that cross‐catalyze each other's formation. The remaining combinations give self‐complementary templates (AB′, BA′) that autocatalyze their own synthesis. As a second prerequisite, the molecular egotists AB′ or BA′ must not outcompete the molecular altruists AA′ and BB′.