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DNA‐Binding Ligands from Peptide Libraries Containing Unnatural Amino Acids
Author(s) -
Lescrinier Theo,
Hendrix Chris,
Kerremans Luc,
Rozenski Jef,
Link Andreas,
Samyn Bart,
Van Aerschot Arthur,
Lescrinier Eveline,
Eritja Ramon,
Van Beeumen Jozef,
Herdewijn Piet
Publication year - 1998
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(19980310)4:3<425::aid-chem425>3.0.co;2-w
Subject(s) - oligonucleotide , peptide , chemistry , dna , combinatorial chemistry , rhodamine , fluorescein , stereochemistry , biochemistry , fluorescence , computational biology , biology , physics , quantum mechanics
Combinatorial chemistry with a newly‐developed screening procedure using complementary fluorescein‐ and rhodamine‐labelled oligonucleotides (below) has been used to select peptide dsDNA binding ligands. A high structure–affinity relationship of the dsDNA‐binding unnatural peptide was observed.