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Efficient Transport of Aromatic Amino Acids by Sapphyrin–Lasalocid Conjugates
Author(s) -
Sessler Jonathan L.,
Andrievsky Andrei
Publication year - 1998
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/(sici)1521-3765(199801)4:1<159::aid-chem159>3.0.co;2-n
Subject(s) - lasalocid , ionophore , conjugate , chemistry , aromatic amino acids , amino acid , covalent bond , porphyrin , membrane , molecule , organic chemistry , combinatorial chemistry , biochemistry , mathematical analysis , mathematics
A novel combination of molecules , sapphyrin (an expanded porphyrin) and lasalocid (a natural polyether ionophore), are covalently linked to produce conjugates (such as 1 ) capable of acting as efficient and selective carriers for aromatic α ‐amino acids, as demonstrated by U‐tube and W‐tube model membrane transport studies.